Endocrine Abstracts

Context: Secondary adrenal insufficiency (SAI) has been identified in over 22% of adults using inhaled corticosteroids (ICS).1 This has been co-related with the total daily dose and type of ICS along with individual genetic susceptibility among the subjects using ICS.1,2 Our recent paper suggested that 2.8% of adults with euvolaemic hyponatremia admitted to the hospital had ICS related SAI.3Objective: To determine prevale...

Context: Hyponatremia is a hormonal disorder of water metabolism encountered in 2% of community dwelling adults in America and in over 15-20% of hospitalized adults.1,2 Hyponatremia leads to increase in risk of falls, cognitive deficits, gait disturbances, loss of independence, prolongation of hospital stay and mortality among older patients admitted to hospitals.3 Objective: To determine in-hospital mortality among older patients ...

Objectives: This study was undertaken to ascertain the prevalence of hearing loss (HL) in patients with Type 2 Diabetes (T2DM) and to understand its relationship with diabetic neuropathy.Materials and Methods: Patients between the ages of 30 to 60 years (both ages inclusive) with T2DM were recruited and divided in two groups. Group 1 with moderate to severe distal sensory-motor neuropathy (Michigan Diabetic Neuropathy Score >12) or Group 2 were those...

Background: Most recent cross sectional and longitudinal studies have failed to find an association between cognitive dysfunction and subclinical hypothyroidism. A recent paper from our country however suggested a significant association.Objectives: This study was undertaken to determine the prevelance of cognitive impairement among educated, elderly Indian patients (>60 years) with and without subclinical hypothyroidism.Materi...

Background: A significant percentage of patients with adequately replaced primary hypothyroidism (PH) continue to be symptomatic. Some of these persisting symptoms maybe attributed to non-restoration of neurocognitive functions and psychological well-being.Objectives: To estimate the prevalence of persisting hypothyroid symptoms in patients with PH on biochemically adequate replacement therapy. To correlate persistent symptoms with thyroid hormone levels...

Context: Studies suggest that 25–40% of men with type 2 diabetes mellitus (T2DM) have hypogonadism. Other studies have estimated that 40–50% of men with T2DM have erectile dysfunction (ED). Some guidelines suggest routine measurements of testosterone in all patients with T2DM.Objectives: To estimate the prevalence of hypogonadism in adult male patients with type 2 diabetes mellitus and symptomatic erectile dysfunction.Met...

Background: Clinical scoring systems were used traditionally in the diagnosis of hypothyroidism before biochemical diagnosis became the norm. There are two well validated clinical scoring systems (Billewicz and Zulewski) for diagnosing hypothyroidism. Both these scores were validated in younger patients with hypothyroidism and may not be useful in older patients. We conducted this study to determine the clinical utility of these two scoring systems among patients over the age ...

Objective: To compare the clinical features, mortality and morbidity outcomes in patients with diabetes mellitus and patients without diabetes mellitus, who are hospitalized with community acquired pneumonia (CAP).Methods: This cross sectional study included 175 patients (49 patients with diabetes and 126 without diabetes) admitted with CAP to a tertiary care hospital. The study included both quantitative and qualitative variables, which were compared us...

Objectives: This study was undertaken to ascertain the prevalence of thyroid dysfunction(TD) in patients with Acute Kidney Injury(AKI) and assess the prognostic implications of TD in AKI patients.Materials and methods: Consecutive adult patients (>18 years) admitted with AKI to the departments of Nephrology & Medicine were recruited if they met AKIN classification criteria for AKI after 48 h of admission (1). Patients were screened for thyroid dy...

Aims: To calculate the sensitivity, specificity and positive predictive value of Parathyroid scintigraphy using Technetium-Sestamibi scan in the localization of parathyroid disease.Methods and material: This is a retrospective medical review of 161 patients who underwent the Parathyroid scintigraphy at our hospital in last six years. True positives were defined as patients with confirmed primary hyperparathyroidism (PHPT) on pathological examination. Tru...